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Structural basis of substrate recognition by human tRNA splicing endonuclease TSEN - Nature Structural & Molecular Biology

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Structural basis of substrate recognition by human tRNA splicing endonuclease TSEN - Nature Structural & Molecular Biology

Heterotetrameric human transfer RNA (tRNA) splicing endonuclease TSEN catalyzes intron excision from precursor tRNAs (pre-tRNAs), utilizing two composite active sites. Mutations in TSEN and its associated RNA kinase CLP1 are linked to the neurodegenerative disease pontocerebellar hypoplasia (PCH).

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Structural basis of substrate recognition by human tRNA splicing endonuclease TSEN - Nature Structural & Molecular Biology

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Structural basis of substrate recognition by human tRNA splicing endonuclease TSEN - Nature Structural & Molecular Biology

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