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Intrinsic mesoscale properties of a Polycomb protein underpin heterochromatin fidelity - Nature Structural & Molecular Biology

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Intrinsic mesoscale properties of a Polycomb protein underpin heterochromatin fidelity - Nature Structural & Molecular Biology

Little is understood about how the two major types of heterochromatin domains (HP1 and Polycomb) are kept separate. In the yeast Cryptococcus neoformans, the Polycomb-like protein Ccc1 prevents deposition of H3K27me3 at HP1 domains. Here we show that phase separation propensity underpins Ccc1 function.

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Intrinsic mesoscale properties of a Polycomb protein underpin heterochromatin fidelity - Nature Structural & Molecular Biology

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Intrinsic mesoscale properties of a Polycomb protein underpin heterochromatin fidelity - Nature Structural & Molecular Biology

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