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A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8 - Nature Communications

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A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8 - Nature Communications

Small animal models have been a challenge for the study of SARS-CoV-2 transmission, with most investigators using golden hamsters or ferrets. Mice have the advantages of low cost, wide availability, less regulatory and husbandry challenges, and the existence of a versatile reagent and genetic toolbox. However, adult mice do not robustly transmit SARS-CoV-2. Here we establish a model based on neonatal mice that allows for transmission of clinical SARS-CoV-2 isolates.

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A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8 - Nature Communications

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A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8 - Nature Communications

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