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Development of miniature base editors using engineered IscB nickase - Nature Methods

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Development of miniature base editors using engineered IscB nickase - Nature Methods

As a miniature RNA-guided endonuclease, IscB is presumed to be the ancestor of Cas9 and to share similar functions. IscB is less than half the size of Cas9 and thus more suitable for in vivo delivery. However, the poor editing efficiency of IscB in eukaryotic cells limits its in vivo applications. Here we describe the engineering of OgeuIscB and its corresponding ωRNA to develop an IscB system that is highly efficient in mammalian systems, named enIscB.

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Development of miniature base editors using engineered IscB nickase - Nature Methods

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Development of miniature base editors using engineered IscB nickase - Nature Methods

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