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Tumour extracellular vesicles and particles induce liver metabolic dysfunction - Nature

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Tumour extracellular vesicles and particles induce liver metabolic dysfunction - Nature

Cancer alters the function of multiple organs beyond those targeted by metastasis1,2. Here we show that inflammation, fatty liver and dysregulated metabolism are hallmarks of systemically affected livers in mouse models and in patients with extrahepatic metastasis. We identified tumour-derived extracellular vesicles and particles (EVPs) as crucial mediators of cancer-induced hepatic reprogramming, which could be reversed by reducing tumour EVP secretion via depletion of Rab27a.

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Tumour extracellular vesicles and particles induce liver metabolic dysfunction - Nature

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Tumour extracellular vesicles and particles induce liver metabolic dysfunction - Nature

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