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Strand-selective base editing of human mitochondrial DNA using mitoBEs - Nature Biotechnology

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Strand-selective base editing of human mitochondrial DNA using mitoBEs - Nature Biotechnology

A number of mitochondrial diseases in humans are caused by point mutations that could be corrected by base editors, but delivery of CRISPR guide RNAs into the mitochondria is difficult. In this study, we present mitochondrial DNA base editors (mitoBEs), which combine a transcription activator-like effector (TALE)-fused nickase and a deaminase for precise base editing in mitochondrial DNA.

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Strand-selective base editing of human mitochondrial DNA using mitoBEs - Nature Biotechnology

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Strand-selective base editing of human mitochondrial DNA using mitoBEs - Nature Biotechnology

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