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ERα-associated translocations underlie oncogene amplifications in breast cancer - Nature

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ERα-associated translocations underlie oncogene amplifications in breast cancer - Nature

Focal copy-number amplification is an oncogenic event. Although recent studies have revealed the complex structure1–3 and the evolutionary trajectories4 of oncogene amplicons, their origin remains poorly understood. Here we show that focal amplifications in breast cancer frequently derive from a mechanism—which we term translocation–bridge amplification—involving inter-chromosomal translocations that lead to dicentric chromosome bridge formation and breakage.

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ERα-associated translocations underlie oncogene amplifications in breast cancer - Nature

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ERα-associated translocations underlie oncogene amplifications in breast cancer - Nature

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