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Nucleolus assembly impairment leads to two-cell transcriptional repression via NPM1-mediated PRC2 recruitment - Nature Structural & Molecular Biology

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Nucleolus assembly impairment leads to two-cell transcriptional repression via NPM1-mediated PRC2 recruitment - Nature Structural & Molecular Biology

The nucleolus is a compartmentalized organelle in eukaryotic cells known to form during embryogenesis, yet how its layered architecture is transformed from homogenous precursor bodies is unclear, and any impacts of this formation on embryonic cell fate determination remain unknown.

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Nucleolus assembly impairment leads to two-cell transcriptional repression via NPM1-mediated PRC2 recruitment - Nature Structural & Molecular Biology

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Nucleolus assembly impairment leads to two-cell transcriptional repression via NPM1-mediated PRC2 recruitment - Nature Structural & Molecular Biology

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