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Polygenic scoring accuracy varies across the genetic ancestry continuum - Nature

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Polygenic scoring accuracy varies across the genetic ancestry continuum - Nature

Polygenic scores (PGSs) have limited portability across different groupings of individuals (for example, by genetic ancestries and/or social determinants of health), preventing their equitable use1–3. PGS portability has typically been assessed using a single aggregate population-level statistic (for example, R2)4, ignoring inter-individual variation within the population.

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Polygenic scoring accuracy varies across the genetic ancestry continuum - Nature

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Polygenic scoring accuracy varies across the genetic ancestry continuum - Nature

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