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Structural basis of NINJ1-mediated plasma membrane rupture in cell death - Nature

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Structural basis of NINJ1-mediated plasma membrane rupture in cell death - Nature

Eukaryotic cells can undergo different forms of programmed cell death, many of which culminate in plasma membrane rupture as the defining terminal event1–7. Plasma membrane rupture was long thought to be driven by osmotic pressure, but it has recently been shown to be in many cases an active process, mediated by the protein ninjurin-18 (NINJ1). Here we resolve the structure of NINJ1 and the mechanism by which it ruptures membranes.

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computer network structural death cell death mediated membrane plasma membrane cell cell biology biology microbiology

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Structural basis of NINJ1-mediated plasma membrane rupture in cell death - Nature

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Structural basis of NINJ1-mediated plasma membrane rupture in cell death - Nature

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