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Conserved stromal–immune cell circuits secure B cell homeostasis and function - Nature Immunology

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Conserved stromal–immune cell circuits secure B cell homeostasis and function - Nature Immunology

B cell zone reticular cells (BRCs) form stable microenvironments that direct efficient humoral immunity with B cell priming and memory maintenance being orchestrated across lymphoid organs. However, a comprehensive understanding of systemic humoral immunity is hampered by the lack of knowledge of global BRC sustenance, function and major pathways controlling BRC–immune cell interactions. Here we dissected the BRC landscape and immune cell interactome in human and murine lymphoid organs.

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Conserved stromal–immune cell circuits secure B cell homeostasis and function - Nature Immunology

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Conserved stromal–immune cell circuits secure B cell homeostasis and function - Nature Immunology

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