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Widespread somatic L1 retrotransposition in normal colorectal epithelium - Nature

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Widespread somatic L1 retrotransposition in normal colorectal epithelium - Nature

Throughout an individual's lifetime, genomic alterations accumulate in somatic cells1–11. However, the mutational landscape induced by retrotransposition of long interspersed nuclear element-1 (L1), a widespread mobile element in the human genome12–14, is poorly understood in normal cells. Here we explored the whole-genome sequences of 899 single-cell clones established from three different cell types collected from 28 individuals.

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Widespread somatic L1 retrotransposition in normal colorectal epithelium - Nature

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Widespread somatic L1 retrotransposition in normal colorectal epithelium - Nature

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