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Structural basis of catalytic activation in human splicing - Nature

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Structural basis of catalytic activation in human splicing - Nature

Pre-mRNA splicing follows a pathway driven by ATP-dependent RNA helicases. A crucial event of the splicing pathway is the catalytic activation, which takes place at the transition between the activated Bact and the branching-competent B* spliceosomes. Catalytic activation occurs through an ATP-dependent remodelling mediated by the helicase PRP2 (also known as DHX16)1–3. However, because PRP2 is observed only at the periphery of spliceosomes3–5, its function has remained elusive.

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Structural basis of catalytic activation in human splicing - Nature

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Structural basis of catalytic activation in human splicing - Nature

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