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In situ architecture of the ER–mitochondria encounter structure - Nature

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In situ architecture of the ER–mitochondria encounter structure - Nature

The endoplasmic reticulum and mitochondria are main hubs of eukaryotic membrane biogenesis that rely on lipid exchange via membrane contact sites1–3, but the underpinning mechanisms remain poorly understood. In yeast, tethering and lipid transfer between the two organelles is mediated by the endoplasmic reticulum–mitochondria encounter structure (ERMES), a four-subunit complex of unresolved stoichiometry and architecture4–6.

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In situ architecture of the ER–mitochondria encounter structure - Nature

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In situ architecture of the ER–mitochondria encounter structure - Nature

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