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Myeloperoxidase inhibition may protect against endothelial glycocalyx shedding induced by COVID-19 plasma - Communications Medicine

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Myeloperoxidase inhibition may protect against endothelial glycocalyx shedding induced by COVID-19 plasma - Communications Medicine

SARS-CoV-2, the causative agent of COVID-19, is a threat to public health. Evidence suggests increased neutrophil activation and endothelial glycocalyx (EG) damage are independently associated with severe COVID-19. Here, we hypothesised that an increased level of blood neutrophil myeloperoxidase (MPO) is associated with soluble EG breakdown, and inhibiting MPO activity may reduce EG damage.

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Myeloperoxidase inhibition may protect against endothelial glycocalyx shedding induced by COVID-19 plasma - Communications Medicine

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Myeloperoxidase inhibition may protect against endothelial glycocalyx shedding induced by COVID-19 plasma - Communications Medicine

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