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A prime editor mouse to model a broad spectrum of somatic mutations in vivo - Nature Biotechnology

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A prime editor mouse to model a broad spectrum of somatic mutations in vivo - Nature Biotechnology

Genetically engineered mouse models only capture a small fraction of the genetic lesions that drive human cancer. Current CRISPR–Cas9 models can expand this fraction but are limited by their reliance on error-prone DNA repair. Here we develop a system for in vivo prime editing by encoding a Cre-inducible prime editor in the mouse germline.

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A prime editor mouse to model a broad spectrum of somatic mutations in vivo - Nature Biotechnology

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A prime editor mouse to model a broad spectrum of somatic mutations in vivo - Nature Biotechnology

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