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PBRM1 loss redirects chromatin remodelling complex to recruit oncogenic factors - Nature Cell Biology

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PBRM1 loss redirects chromatin remodelling complex to recruit oncogenic factors - Nature Cell Biology

The loss of the polybromo-1 (PBRM1) subunit in a class of SWI/SNF chromatin remodelling complexes in clear cell renal cell carcinoma redirects the deficient complexes to aberrant enhancer regions. The catalytic subunit SMARCA4 of the PBRM1-deficient complexes recruits the nuclear factor-κB transcription factor to drive pro-tumorigenic programs.

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PBRM1 loss redirects chromatin remodelling complex to recruit oncogenic factors - Nature Cell Biology

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PBRM1 loss redirects chromatin remodelling complex to recruit oncogenic factors - Nature Cell Biology

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