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Motifs for making tricycles - Nature Chemical Biology

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Motifs for making tricycles - Nature Chemical Biology

Tricyclic peptides have reduced conformational flexibility, making them well suited for ligand development. Researchers have now generated large combinatorial libraries of tricyclic peptides using a disulfide-directing motif. Screening these libraries discovered binders to challenging protein targets.

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Motifs for making tricycles - Nature Chemical Biology

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Motifs for making tricycles - Nature Chemical Biology

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