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Ligand and G-protein selectivity in the κ-opioid receptor - Nature

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Ligand and G-protein selectivity in the κ-opioid receptor - Nature

The κ-opioid receptor (KOR) represents a highly desirable therapeutic target for treating not only pain but also addiction and affective disorders1. However, the development of KOR analgesics has been hindered by the associated hallucinogenic side effects2. The initiation of KOR signalling requires the Gi/o-family proteins including the conventional (Gi1, Gi2, Gi3, GoA and GoB) and nonconventional (Gz and Gg) subtypes.

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Ligand and G-protein selectivity in the κ-opioid receptor - Nature

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Ligand and G-protein selectivity in the κ-opioid receptor - Nature

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