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Engineered phage with antibacterial CRISPR–Cas selectively reduce E. coli burden in mice - Nature Biotechnology

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Engineered phage with antibacterial CRISPR–Cas selectively reduce E. coli burden in mice - Nature Biotechnology

Antibiotic treatments have detrimental effects on the microbiome and lead to antibiotic resistance. To develop a phage therapy against a diverse range of clinically relevant Escherichia coli, we screened a library of 162 wild-type (WT) phages, identifying eight phages with broad coverage of E. coli, complementary binding to bacterial surface receptors, and the capability to stably carry inserted cargo.

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Engineered phage with antibacterial CRISPR–Cas selectively reduce E. coli burden in mice - Nature Biotechnology

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Engineered phage with antibacterial CRISPR–Cas selectively reduce E. coli burden in mice - Nature Biotechnology

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