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A phosphate-sensing organelle regulates phosphate and tissue homeostasis - Nature

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A phosphate-sensing organelle regulates phosphate and tissue homeostasis - Nature

Inorganic phosphate (Pi) is one of the essential molecules for life. However, little is known about intracellular Pi metabolism and signalling in animal tissues1. Following the observation that chronic Pi starvation causes hyperproliferation in the digestive epithelium of Drosophila melanogaster, we determined that Pi starvation triggers the downregulation of the Pi transporter PXo. In line with Pi starvation, PXo deficiency caused midgut hyperproliferation.

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A phosphate-sensing organelle regulates phosphate and tissue homeostasis - Nature

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A phosphate-sensing organelle regulates phosphate and tissue homeostasis - Nature

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