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A high-throughput platform for efficient exploration of functional polypeptide chemical space - Nature Synthesis

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A high-throughput platform for efficient exploration of functional polypeptide chemical space - Nature Synthesis

Rapid and in-depth exploration of the chemical space of high-molecular-weight synthetic polypeptides via ring-opening polymerization of N-carboxyanhydride allows the discovery of protein mimics and functional biomaterials. The traditional synthetic workflow, however, is labour intensive and has limited throughput. Here we develop an approach for the high-throughput diversification of polypeptides based on a click-like reaction between selenolate and various electrophiles in aqueous solutions.

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A high-throughput platform for efficient exploration of functional polypeptide chemical space - Nature Synthesis

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A high-throughput platform for efficient exploration of functional polypeptide chemical space - Nature Synthesis

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Unlocking the Power of Knowledge
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