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The unique properties of IgG4 and its roles in health and disease - Nature Reviews Immunology

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The unique properties of IgG4 and its roles in health and disease - Nature Reviews Immunology

IgG4 is the least abundant subclass of IgG in human serum and has unique functional features. IgG4 is largely unable to activate antibody-dependent immune effector responses and, furthermore, undergoes Fab (fragment antigen binding)-arm exchange, rendering it bispecific for antigen binding and functionally monovalent. These properties of IgG4 have a blocking effect, either on the immune response or on the target protein of IgG4.

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The unique properties of IgG4 and its roles in health and disease - Nature Reviews Immunology

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The unique properties of IgG4 and its roles in health and disease - Nature Reviews Immunology

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