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Amino acids downregulate SIRT4 to detoxify ammonia through the urea cycle - Nature Metabolism

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Amino acids downregulate SIRT4 to detoxify ammonia through the urea cycle - Nature Metabolism

Ammonia production via glutamate dehydrogenase is inhibited by SIRT4, a sirtuin that displays both amidase and non-amidase activities. The processes underlying the regulation of ammonia removal by amino acids remain unclear. Here, we report that SIRT4 acts as a decarbamylase that responds to amino acid sufficiency and regulates ammonia removal. Amino acids promote lysine 307 carbamylation (OTCCP-K307) of ornithine transcarbamylase (OTC), which activates OTC and the urea cycle.

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Amino acids downregulate SIRT4 to detoxify ammonia through the urea cycle - Nature Metabolism

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Amino acids downregulate SIRT4 to detoxify ammonia through the urea cycle - Nature Metabolism

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