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A positive feedback loop controls Toxoplasma chronic differentiation - Nature Microbiology

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A positive feedback loop controls Toxoplasma chronic differentiation - Nature Microbiology

Successful infection strategies must balance pathogen amplification and persistence. In the obligate intracellular parasite Toxoplasma gondii this is accomplished through differentiation into dedicated cyst-forming chronic stages that avoid clearance by the host immune system. The transcription factor BFD1 is both necessary and sufficient for stage conversion; however, its regulation is not understood. In this study we examine five factors that are transcriptionally activated by BFD1.

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A positive feedback loop controls Toxoplasma chronic differentiation - Nature Microbiology

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A positive feedback loop controls Toxoplasma chronic differentiation - Nature Microbiology

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