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Human primase hangs on the primer–template and Polα to facilitate primer termination - Nature Structural & Molecular Biology

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Human primase hangs on the primer–template and Polα to facilitate primer termination - Nature Structural & Molecular Biology

We determined the structure of the Polα–primase complex trapped in a DNA elongation state. Cryo-electron microscopy showed that primase has a role in facilitating the timely termination of primer DNA elongation by Polα by hanging on the primer–template complex.

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Human primase hangs on the primer–template and Polα to facilitate primer termination - Nature Structural & Molecular Biology

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Human primase hangs on the primer–template and Polα to facilitate primer termination - Nature Structural & Molecular Biology

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