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Partially hydrolyzed guar gum increased colonic mucus layer in mice via succinate-mediated MUC2 production - npj Science of Food

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Partially hydrolyzed guar gum increased colonic mucus layer in mice via succinate-mediated MUC2 production - npj Science of Food

Colonic mucus layers protect intestinal tissues against intestinal bacteria. We investigated the effects of dietary fiber and its metabolites on mucus production in the colonic mucosa. Mice were fed a partially hydrolyzed guar gum (PHGG)-containing diet and a fiber-free diet (FFD). The colon mucus layer, fecal short-chain fatty acid (SCFA) levels, and gut microbiota were evaluated. Mucin 2 (MUC2) expression was assessed in SCFA-treated LS174T cells.

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Partially hydrolyzed guar gum increased colonic mucus layer in mice via succinate-mediated MUC2 production - npj Science of Food

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Partially hydrolyzed guar gum increased colonic mucus layer in mice via succinate-mediated MUC2 production - npj Science of Food

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