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Quantification of localized NAD+ changes reveals unique specificity of NAD+ regulation in the hypothalamus - npj Aging

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Quantification of localized NAD+ changes reveals unique specificity of NAD+ regulation in the hypothalamus - npj Aging

Recently, it has become a consensus that systemic decreases in NAD+ are a critical trigger for age-associated functional decline in multiple tissues and organs. The hypothalamus, which contains several functionally distinct subregions called nuclei, functions as a high-order control center of aging in mammals. However, due to a technical difficulty, how NAD+ levels change locally in each hypothalamic nucleus during aging remains uninvestigated.

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Quantification of localized NAD+ changes reveals unique specificity of NAD+ regulation in the hypothalamus - npj Aging

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Quantification of localized NAD+ changes reveals unique specificity of NAD+ regulation in the hypothalamus - npj Aging

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