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The transcriptional and regulatory identity of erythropoietin producing cells - Nature Medicine

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The transcriptional and regulatory identity of erythropoietin producing cells - Nature Medicine

Erythropoietin (Epo) is the master regulator of erythropoiesis and oxygen homeostasis. Despite its physiological importance, the molecular and genomic contexts of the cells responsible for renal Epo production remain unclear, limiting more-effective therapies for anemia. Here, we performed single-cell RNA and transposase-accessible chromatin (ATAC) sequencing of an Epo reporter mouse to molecularly identify Epo-producing cells under hypoxic conditions.

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health education transcriptional erythropoietin cells cell biology biology microbiology

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The transcriptional and regulatory identity of erythropoietin producing cells - Nature Medicine

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The transcriptional and regulatory identity of erythropoietin producing cells - Nature Medicine

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