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Tailoring renal-clearable zwitterionic cyclodextrin for colorectal cancer-selective drug delivery - Nature Nanotechnology

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Tailoring renal-clearable zwitterionic cyclodextrin for colorectal cancer-selective drug delivery - Nature Nanotechnology

Although cyclodextrin-based renal-clearable nanocarriers have a high potential for clinical translation in targeted cancer therapy, their designs remain to be optimized for tumour retention. Here we report on the design of a tailored structure for renal-clearable zwitterionic cyclodextrin for colorectal cancer-selective drug delivery. Twenty cyclodextrin derivatives with different charged moieties and spacers are synthesized and screened for colloidal stability.

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Tailoring renal-clearable zwitterionic cyclodextrin for colorectal cancer-selective drug delivery - Nature Nanotechnology

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Tailoring renal-clearable zwitterionic cyclodextrin for colorectal cancer-selective drug delivery - Nature Nanotechnology

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