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Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience - Nature Neuroscience

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Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience - Nature Neuroscience

Pathological hallmarks of Alzheimer's disease (AD) precede clinical symptoms by years, indicating a period of cognitive resilience before the onset of dementia. Here, we report that activation of cyclic GMP–AMP synthase (cGAS) diminishes cognitive resilience by decreasing the neuronal transcriptional network of myocyte enhancer factor 2c (MEF2C) through type I interferon (IFN-I) signaling.

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Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience - Nature Neuroscience

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Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience - Nature Neuroscience

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