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Participation bias in the UK Biobank distorts genetic associations and downstream analyses - Nature Human Behaviour

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Participation bias in the UK Biobank distorts genetic associations and downstream analyses - Nature Human Behaviour

While volunteer-based studies such as the UK Biobank have become the cornerstone of genetic epidemiology, the participating individuals are rarely representative of their target population. To evaluate the impact of selective participation, here we derived UK Biobank participation probabilities on the basis of 14 variables harmonized across the UK Biobank and a representative sample. We then conducted weighted genome-wide association analyses on 19 traits.

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Participation bias in the UK Biobank distorts genetic associations and downstream analyses - Nature Human Behaviour

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Participation bias in the UK Biobank distorts genetic associations and downstream analyses - Nature Human Behaviour

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