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BICD2 phosphorylation regulates dynein function and centrosome separation in G2 and M - Nature Communications

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BICD2 phosphorylation regulates dynein function and centrosome separation in G2 and M - Nature Communications

The activity of dynein is regulated by a number of adaptors that mediate its interaction with dynactin, effectively activating the motor complex while also connecting it to different cargos. The regulation of adaptors is consequently central to dynein physiology but remains largely unexplored. We now describe that one of the best-known dynein adaptors, BICD2, is effectively activated through phosphorylation. In G2, phosphorylation of BICD2 by CDK1 promotes its interaction with PLK1.

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BICD2 phosphorylation regulates dynein function and centrosome separation in G2 and M - Nature Communications

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BICD2 phosphorylation regulates dynein function and centrosome separation in G2 and M - Nature Communications

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