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The Smc5/6 complex is a DNA loop-extruding motor - Nature

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The Smc5/6 complex is a DNA loop-extruding motor - Nature

Structural maintenance of chromosomes (SMC) protein complexes are essential for the spatial organization of chromosomes1. Whereas cohesin and condensin organize chromosomes by extrusion of DNA loops, the molecular functions of the third eukaryotic SMC complex, Smc5/6, remain largely unknown2. Using single-molecule imaging, we show that Smc5/6 forms DNA loops by extrusion. Upon ATP hydrolysis, Smc5/6 reels DNA symmetrically into loops at a force-dependent rate of one kilobase pair per second.

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The Smc5/6 complex is a DNA loop-extruding motor - Nature

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The Smc5/6 complex is a DNA loop-extruding motor - Nature

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