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Pigmentation and TYRP1 expression are mediated by zinc through the early secretory pathway-resident ZNT proteins - Communications Biology

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Pigmentation and TYRP1 expression are mediated by zinc through the early secretory pathway-resident ZNT proteins - Communications Biology

Tyrosinase (TYR) and tyrosinase-related proteins 1 and 2 (TYRP1 and TYRP2) are essential for pigmentation. They are generally classified as type-3 copper proteins, with binuclear copper active sites. Although there is experimental evidence for a copper cofactor in TYR, delivered via the copper transporter, ATP7A, the presence of copper in TYRP1 and TYRP2 has not been demonstrated.

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Pigmentation and TYRP1 expression are mediated by zinc through the early secretory pathway-resident ZNT proteins - Communications Biology

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Pigmentation and TYRP1 expression are mediated by zinc through the early secretory pathway-resident ZNT proteins - Communications Biology

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