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Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease - Nature Medicine

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Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease - Nature Medicine

Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance imaging marker of cerebral small vessel disease, a leading cause of stroke and dementia. Genome-wide association studies in up to 40,095 participants (18 population-based cohorts, 66.3 ± 8.6 yr, 96.9% European ancestry) revealed 24 genome-wide significant PVS risk loci, mainly in the white matter.

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Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease - Nature Medicine

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Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease - Nature Medicine

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