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Progress towards a glycoconjugate vaccine against Group A Streptococcus - npj Vaccines

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Progress towards a glycoconjugate vaccine against Group A Streptococcus - npj Vaccines

The Group A Carbohydrate (GAC) is a defining feature of Group A Streptococcus (Strep A) or Streptococcus pyogenes. It is a conserved and simple polysaccharide, comprising a rhamnose backbone and GlcNAc side chains, further decorated with glycerol phosphate on approximately 40% GlcNAc residues. Its conservation, surface exposure and antigenicity have made it an interesting focus on Strep A vaccine design.

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Progress towards a glycoconjugate vaccine against Group A Streptococcus - npj Vaccines

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Progress towards a glycoconjugate vaccine against Group A Streptococcus - npj Vaccines

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