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Replication licensing during S phase: breaking the law to prevent breaking DNA - Nature Structural & Molecular Biology

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Replication licensing during S phase: breaking the law to prevent breaking DNA - Nature Structural & Molecular Biology

A cardinal rule of DNA replication is to prevent any possibility of pre-replication complexes re-loading during S phase, risking genotoxic over-replication. But can this rule be broken in emergency situations to preserve genome integrity?

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Replication licensing during S phase: breaking the law to prevent breaking DNA - Nature Structural & Molecular Biology

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Replication licensing during S phase: breaking the law to prevent breaking DNA - Nature Structural & Molecular Biology

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