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Precise modulation of transcription factor levels identifies features underlying dosage sensitivity - Nature Genetics

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Precise modulation of transcription factor levels identifies features underlying dosage sensitivity - Nature Genetics

Transcriptional regulation exhibits extensive robustness, but human genetics indicates sensitivity to transcription factor (TF) dosage. Reconciling such observations requires quantitative studies of TF dosage effects at trait-relevant ranges, largely lacking so far.

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Precise modulation of transcription factor levels identifies features underlying dosage sensitivity - Nature Genetics

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Precise modulation of transcription factor levels identifies features underlying dosage sensitivity - Nature Genetics

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