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Repurposing degradation pathways for modular metabolite biosynthesis in nematodes - Nature Chemical Biology

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Repurposing degradation pathways for modular metabolite biosynthesis in nematodes - Nature Chemical Biology

Recent studies have revealed that Caenorhabditis elegans and other nematodes repurpose products from biochemical degradation pathways for the combinatorial assembly of complex modular structures that serve diverse signaling functions. Building blocks from neurotransmitter, amino acid, nucleoside and fatty acid metabolism are attached to scaffolds based on the dideoxyhexose ascarylose or glucose, resulting in hundreds of modular ascarosides and glucosides.

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Repurposing degradation pathways for modular metabolite biosynthesis in nematodes - Nature Chemical Biology

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Repurposing degradation pathways for modular metabolite biosynthesis in nematodes - Nature Chemical Biology

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