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Large-scale mapping and mutagenesis of human transcriptional effector domains - Nature

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Large-scale mapping and mutagenesis of human transcriptional effector domains - Nature

Human gene expression is regulated by more than 2,000 transcription factors and chromatin regulators1,2. Effector domains within these proteins can activate or repress transcription. However, for many of these regulators we do not know what type of effector domains they contain, their location in the protein, their activation and repression strengths, and the sequences that are necessary for their functions.

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Large-scale mapping and mutagenesis of human transcriptional effector domains - Nature

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Large-scale mapping and mutagenesis of human transcriptional effector domains - Nature

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