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Prefrontal engrams of long-term fear memory perpetuate pain perception - Nature Neuroscience

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Prefrontal engrams of long-term fear memory perpetuate pain perception - Nature Neuroscience

A painful episode can lead to a life-long increase in an individual's experience of pain. Fearful anticipation of imminent pain could play a role in this phenomenon, but the neurobiological underpinnings are unclear because fear can both suppress and enhance pain. Here, we show in mice that long-term associative fear memory stored in neuronal engrams in the prefrontal cortex determines whether a painful episode shapes pain experience later in life.

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Prefrontal engrams of long-term fear memory perpetuate pain perception - Nature Neuroscience

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Prefrontal engrams of long-term fear memory perpetuate pain perception - Nature Neuroscience

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