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The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells - Nature

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The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells - Nature

Natural killer (NK) cell kill infected, transformed and stressed cells when an activating NK cell receptor is triggered1. Most NK cells and some innate lymphoid cells express the activating receptor NKp46, encoded by NCR1, the most evolutionarily ancient NK cell receptor2,3. Blockage of NKp46 inhibits NK killing of many cancer targets4. Although a few infectious NKp46 ligands have been identified, the endogenous NKp46 cell surface ligand is unknown.

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The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells - Nature

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The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells - Nature

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