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Epicardioid single-cell genomics uncovers principles of human epicardium biology in heart development and disease - Nature Biotechnology

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Epicardioid single-cell genomics uncovers principles of human epicardium biology in heart development and disease - Nature Biotechnology

The epicardium, the mesothelial envelope of the vertebrate heart, is the source of multiple cardiac cell lineages during embryonic development and provides signals that are essential to myocardial growth and repair. Here we generate self-organizing human pluripotent stem cell-derived epicardioids that display retinoic acid-dependent morphological, molecular and functional patterning of the epicardium and myocardium typical of the left ventricular wall.

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Epicardioid single-cell genomics uncovers principles of human epicardium biology in heart development and disease - Nature Biotechnology

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Epicardioid single-cell genomics uncovers principles of human epicardium biology in heart development and disease - Nature Biotechnology

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