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PIEZO1 and PECAM1 interact at cell-cell junctions and partner in endothelial force sensing - Communications Biology

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PIEZO1 and PECAM1 interact at cell-cell junctions and partner in endothelial force sensing - Communications Biology

Two prominent concepts for the sensing of shear stress by endothelium are the PIEZO1 channel as a mediator of mechanically activated calcium ion entry and the PECAM1 cell adhesion molecule as the apex of a triad with CDH5 and VGFR2. Here, we investigated if there is a relationship. By inserting a non-disruptive tag in native PIEZO1 of mice, we reveal in situ overlap of PIEZO1 with PECAM1.

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PIEZO1 and PECAM1 interact at cell-cell junctions and partner in endothelial force sensing - Communications Biology

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PIEZO1 and PECAM1 interact at cell-cell junctions and partner in endothelial force sensing - Communications Biology

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