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The protease calpain2a limits innate immunity by targeting TRAF6 in teleost fish - Communications Biology

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The protease calpain2a limits innate immunity by targeting TRAF6 in teleost fish - Communications Biology

TNF receptor-associated factor 6 (TRAF6) plays a key signal transduction role in both antibacterial and antiviral signaling pathways. However, the regulatory mechanisms of TRAF6 in lower vertebrates are less reported. In this study, we identify calpain2a, is a member of the calcium-dependent proteases family with unique hydrolytic enzyme activity, functions as a key regulator for antibacterial and antiviral immunity in teleost fish.

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The protease calpain2a limits innate immunity by targeting TRAF6 in teleost fish - Communications Biology

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The protease calpain2a limits innate immunity by targeting TRAF6 in teleost fish - Communications Biology

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