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The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities - Nature Structural & Molecular Biology

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The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities - Nature Structural & Molecular Biology

The DNA-repair capacity in somatic cells is limited compared with that in germ cells. It has remained unknown whether not only lesion-type-specific, but overall repair capacities could be improved. Here we show that the DREAM repressor complex curbs the DNA-repair capacities in somatic tissues of Caenorhabditis elegans. Mutations in the DREAM complex induce germline-like expression patterns of multiple mechanisms of DNA repair in the soma.

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The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities - Nature Structural & Molecular Biology

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The DREAM complex functions as conserved master regulator of somatic DNA-repair capacities - Nature Structural & Molecular Biology

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