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Loss of H3K9 trimethylation alters chromosome compaction and transcription factor retention during mitosis - Nature Structural & Molecular Biology

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Loss of H3K9 trimethylation alters chromosome compaction and transcription factor retention during mitosis - Nature Structural & Molecular Biology

Recent studies have shown that repressive chromatin machinery, including DNA methyltransferases and polycomb repressor complexes, binds to chromosomes throughout mitosis and their depletion results in increased chromosome size. In the present study, we show that enzymes that catalyze H3K9 methylation, such as Suv39h1, Suv39h2, G9a and Glp, are also retained on mitotic chromosomes.

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Loss of H3K9 trimethylation alters chromosome compaction and transcription factor retention during mitosis - Nature Structural & Molecular Biology

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Loss of H3K9 trimethylation alters chromosome compaction and transcription factor retention during mitosis - Nature Structural & Molecular Biology

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