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Measuring the impact of chromatin context on transcription factor binding affinities - Nature Biotechnology

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Measuring the impact of chromatin context on transcription factor binding affinities - Nature Biotechnology

We have designed a method, binding affinities to native chromatin by sequencing (BANC-seq), to determine the transcription factor concentrations required for binding to regulatory elements across the genome. Our study shows that chromatin context and DNA accessibility are key regulators of transcription factor binding.

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Measuring the impact of chromatin context on transcription factor binding affinities - Nature Biotechnology

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Measuring the impact of chromatin context on transcription factor binding affinities - Nature Biotechnology

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