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Unbalanced response to growth variations reshapes the cell fate decision landscape - Nature Chemical Biology

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Unbalanced response to growth variations reshapes the cell fate decision landscape - Nature Chemical Biology

The global regulation of cell growth rate on gene expression perturbs the performance of gene networks, which would impose complex variations on the cell-fate decision landscape. Here we use a simple synthetic circuit of mutual repression that allows a bistable landscape to examine how such global regulation would affect the stability of phenotypic landscape and the accompanying dynamics of cell-fate determination.

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Unbalanced response to growth variations reshapes the cell fate decision landscape - Nature Chemical Biology

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Unbalanced response to growth variations reshapes the cell fate decision landscape - Nature Chemical Biology

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